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lipids dphpc  (Croda International Plc)
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A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% <t>cholesterol</t> (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.
Lipids Dphpc, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1 2 diphytanoyl sn glycero 3 phosphocholine dphpc  (Croda International Plc)
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A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% <t>cholesterol</t> (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.
1 2 Diphytanoyl Sn Glycero 3 Phosphocholine Dphpc, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% <t>cholesterol</t> (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.
Diphytanoyl Sn Glycero 3 Phosphocholine Dphpc Avanti Polar Lipids 850356c 4, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1 2 diphytanoyl sn glycerol 3 phosphocholine dphpc  (Croda International Plc)
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A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% <t>cholesterol</t> (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.
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A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% <t>cholesterol</t> (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.
1 2 Diphytanoyl Sn 709 Glycerol 3 Phosphocholine Dphpc, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% <t>cholesterol</t> (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.
Dphpc, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 97/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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dphpc lipid  (Croda International Plc)
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A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% <t>cholesterol</t> (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.
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Image Search Results


A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% cholesterol (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.

Journal: bioRxiv

Article Title: PKD2 structural destabilization drives primary cilia degeneration and ADPKD pathogenicity

doi: 10.64898/2026.06.24.734313

Figure Lengend Snippet: A ) Left , image of a voltage clamped primary cilia in the on-cilia configuration. The primary cilium of HEK (PKD1 Null :PKD2 Null ) cells transiently expressing PKD2 channels are illuminated by ARL13B-GFP under 475 nm laser excitation. Right , example single channel recordings from the cilia membrane activated by depolarizing voltage steps. Note, no open channel events were observed in cilia patch recordings from cells expressing D511V channels. B ) Left , example polycystin unitary single channel events recorded from cilia membranes. Right , corresponding histograms indicating the frequency of a variable simultaneous open channel events (O 1 -O 3 ) and closure (C). Note, no channel openings are detected from cilia recordings from cells expressing D511V channels. C ) Column plots indicating the frequency of the maximum simultaneous open channel events from cilia patches. Number of events are indicated in parenthesis. D ) Image of a voltage clamped giant unilaminear vesicals (GUVs) reconstituted with cell free expressed PKD2-GFP protein. E ) Top , example WT PKD2-GFP unitary single channel events recorded (HP = 40mV) from GUVs composed of either 1,2-diphytanoyl-sn-glycero-phosphocholine (DPhPC) or 95% DPhPC and 5% cholesterol (Bovine). Bottom , lack of single channel events from D511V channels reconstituted in GUVs. F ) Column plots indicating the frequency of the maximum simultaneous open channel events from GUVs patches. Number of recordings indicated above for each column.

Article Snippet: Lipids DPhPC (95%) and cholesterol (bovine, 5%) were obtained from Avanti Polar Lipids (Alabaster, USA) and mixed in chloroform, where vacuum evaporation on glass formed small unilaminar vesicles (SUVs), rehydrated and passed through a 100-nm polycarbonate filter with a Mini-Extruder (Avanti Polar Lipids).

Techniques: Expressing, Membrane